A common question among pre-diabetic individuals is whether Metformin can help, especially when a doctor has not yet prescribed it. One Quora user asked if taking 250 mg instead of the standard 500 mg starting dose could reduce carbohydrate cravings. Experts clarify that pre-diabetes treatment typically begins with intensive lifestyle changes such as diet, exercise, and weight loss. If blood sugar levels remain elevated after about six months, medications like Metformin may be introduced. The standard starting dose for pre-diabetes is 500 mg once daily, the same as for type 2 diabetes. Metformin works by reducing glucose production in the liver, improving insulin sensitivity, and enhancing glucose uptake in muscles. While it may help stabilize blood sugar and reduce carb cravings, the effectiveness of a 250 mg dose is not well-researched. Consulting a doctor before starting any dosage is essential.
Starting Metformin and Understanding the Right Dosage
Dr. Rajiv Kovil, head of diabetology at Zandra Healthcare, explains that the starting dose of Metformin in pre-diabetes is 500 mg once daily, identical to the dosage for type 2 diabetes. Most patients can increase to 500 mg twice daily after a week or two if tolerated, with a goal of 1,500 to 2,000 mg per day for full effect. Dr. Narander Singla, lead consultant at CK Birla Hospital, notes that doctors may start with 500 mg once or twice daily, gradually increasing based on tolerance and blood sugar response. Extended-release formulations are also available and easier to tolerate. Importantly, renal function should be checked before and during therapy, and Metformin works best alongside balanced diet, regular exercise, and weight loss.
Source: Link