Common medicines prescribed for managing blood pressure and blood sugar can lead to swelling in the feet and ankles, according to medical experts. Amlodipine, a widely used blood pressure medication, and Pioglitazone, prescribed for controlling blood sugar in type 2 diabetes, are identified as the main causes of this side effect. The swelling, known medically as pedal edema, occurs because these drugs either cause fluid leakage into tissues or promote the retention of sodium and water in the body. Pregabalin, a medicine for nerve pain, can also result in similar puffiness. Experts emphasize that patients experiencing such symptoms should inform their doctors promptly rather than stopping the medication on their own. Dose adjustments or switching to alternative drugs may be necessary. Regular medical supervision and timely follow-up are essential to manage both the underlying health condition and any side effects effectively.
How These Medications Cause Swelling in Feet
Amlodipine, a calcium channel blocker, works by relaxing blood vessels to lower blood pressure. However, it causes dilation of small arteries, which leads to fluid leaking into surrounding tissues, particularly in the feet and ankles. Pioglitazone, used for managing blood sugar in type 2 diabetes, promotes sodium and water retention in the body. Both medications can cause soft, pitting ankle swelling, especially in older adults or individuals taking higher doses. Pregabalin, often prescribed for nerve pain, increases capillary permeability and venous pooling, resulting in noticeable foot and ankle puffiness. These side effects do not occur in everyone but are common enough to warrant attention and proper medical guidance.
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